Novel antioxidants based on phosphonates bearing 2,6-di-tert-butylphenol

被引：0

作者：

Milaeva, E. R. ^{[1
]}

Filimonova, S., I ^{[1
]}

Tarasevich, B. N. ^{[1
]}

Prishchenko, A. A. ^{[1
]}

Livantsov, M., V ^{[1
]}

Novikova, O. P. ^{[1
]}

Livantsova, L., I ^{[1
]}

Dubova, L. G. ^{[2
]}

Shevtsova, E. F. ^{[2
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Organ Chem, Moscow 117234, Russia

[2] Russian Acad Sci, Inst Physiol Act Compounds, Moscow, Russia

来源：

10TH EUROPEAN BIOLOGICAL INORGANIC CHEMISTRY CONFERENCE (EUROBIC10) | 2010年

关键词：

2,6-DI-TERT-BUTYL-4-METHYLPHENOL; DERIVATIVES;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antioxidative activity of phosphonates bearing 2,6-di-tert-butylphenol or phenyl groups has been compared using DPPH test and in the study of the in vitro impact mitochondrial membrane lipid peroxidation. The results show that the activity depends strongly upon the presence of phenolic group but is improved by the influence of phosphonate fragment. It should be noted, that the most active compounds aganst Fe3+-induced peroxidation (5b, 7a and 7b) significantly decreased membrane potential of mitochondria and induced mitochondria swelling. At the same time active compounds 1, 2a and 6a did not influence the mitochondrial potential and swelling.

引用

页码：15 / 22

页数：8

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