Using proteomics to identify potential therapeutic targets in platelets

被引：15
|
作者：
Maguire, FB [1 ]
Foy, M [1 ]
Fitzgerald, DJ [1 ]
机构：
[1] Univ Coll Dublin, Conway Inst, Dept Mol Med, Dublin 4, Ireland
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷
关键词：
MS; membrane lipid raft; platelet phosphoproteome; platelet releasate; platelet; proteomics;
D O I：
10.1042/BST0330409
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Proteomics has provided powerful new insights into the complex events of the anucleate platelet and has revealed many potential protein targets in the search for suitable agents for thrombotic disease. in the present study, we summarize recent proteomic approaches to analyse specific platelet subproteomes, such as the platelet releasate, the platelet phosphotyrosine proteome and characterization of the proteins associated with membrane lipid rafts.
引用
收藏
页码：409 / 412
页数：4
相关论文
共 50 条
  • [41] Using Drosophila melanogaster to identify Angelman syndrome therapeutic targets.
    Reiter, LT
    Bowers, M
    Bier, E
    AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (04) : 526 - 526
  • [42] Platelets, atherosclerosis and the endothelium: new therapeutic targets?
    Tan, MT
    Lip, GY
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2003, 12 (11) : 1765 - 1776
  • [43] Morphoproteomics: exposing protein circuitries in tumors to identify potential therapeutic targets in cancer patients
    Brown, RE
    EXPERT REVIEW OF PROTEOMICS, 2005, 2 (03) : 337 - 348
  • [44] Characterization of the Estrogen Response Helps to Predict Prognosis and Identify Potential Therapeutic Targets in Cholangiocarcinoma
    Lu, Chenglin
    Miao, Ji
    Li, Minhuan
    Zheng, Qisi
    Xu, Feng
    Pan, Yiming
    Wang, Yizhou
    Yang, Zhi
    Xia, Xuefeng
    Zhu, Hao
    Chen, Jie
    Bao, Shanhua
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [45] Development and Evaluation of Antibody Proteomics Technology for Rapid and Comprehensive Identification of Potential Biomarkers and Therapeutic Targets
    Nagano, Kazuya
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2018, 41 (05) : 663 - 669
  • [46] Quantitative Proteomics and Metabolomics Reveal Biomarkers of Disease as Potential Immunotherapy Targets and Indicators of Therapeutic Efficacy
    MacMullan, Melanie A.
    Dunn, Zachary S.
    Graham, Nicolas
    Yang, Lili
    Wang, Pin
    THERANOSTICS, 2019, 9 (25): : 7872 - 7888
  • [47] Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma
    Wang, Zhi
    Jiang, Lu
    Huang, Canhua
    Li, Zhengyu
    Chen, Lijuan
    Gou, Lantu
    Chen, Ping
    Tong, Aiping
    Tang, Minghai
    Gao, Feng
    Shen, Jun
    Zhang, Yuanyuan
    Bai, Jingping
    Zhou, Min
    Miao, Di
    Chen, Qianming
    MOLECULAR & CELLULAR PROTEOMICS, 2008, 7 (09) : 1639 - 1650
  • [48] Quantitative Proteomics of the Neisseria Gonorrhoeae Cell Envelope and Membrane Vesicles for the Discovery of Potential Therapeutic Targets
    Zielke, Ryszard A.
    Wierzbicki, Igor H.
    Weber, Jacob V.
    Gafken, Philip R.
    Sikora, Aleksandra E.
    MOLECULAR & CELLULAR PROTEOMICS, 2014, 13 (05) : 1299 - 1317
  • [49] Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease
    Mazidi, Mohsen
    Wright, Neil
    Yao, Pang
    Kartsonaki, Christiana
    Millwood, Iona Y.
    Fry, Hannah
    Said, Saredo
    Pozarickij, Alfred
    Pei, Pei
    Chen, Yiping
    Avery, Daniel
    Du, Huaidong
    Schmidt, Dan Valle
    Yang, Ling
    Lv, Jun
    Yu, Canqing
    Chen, Junshi
    Hill, Michael
    Holmes, Michael, V
    Howson, Joanna M. M.
    Peto, Richard
    Collins, Rory
    Bennett, Derrick A.
    Walters, Robin G.
    Li, Liming
    Clarke, Robert
    Chen, Zhengming
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2023, 82 (20) : 1906 - 1920
  • [50] MicroRNA Dysregulation to Identify Novel Therapeutic Targets
    Croce, Carlo M.
    VIRUSES, GENES, AND CANCER, 2017, 407 : 191 - 203
12345