A novel mutation in the interleukin-2 receptor γ gene as the cause of lymphopenia in a neonate vertically exposed to human immunodeficiency

被引：1

作者：

Neubert, J ^{[1
]}

Meindl, A

Theisen, A

Adams, O

Schulz, A

Feyen, O

Niehues, T

机构：

[1] Univ Dusseldorf, Childrens Hosp, Div Pediat & Rheumatol, D-4000 Dusseldorf, Germany

[2] Univ Dusseldorf, Dept Virol, D-4000 Dusseldorf, Germany

[3] Univ Munich, Inst Human Genet, Munich, Germany

[4] Univ Ulm, Childrens Hosp, Ulm, Germany

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2005年 / 24卷 / 02期

关键词：

gene mutation; human immunodeficiency virus infection; lymphopenia;

D O I：

10.1097/01.inf.0000148934.36915.5d

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Perinatal transmission prophylaxis has led to a significant reduction of vertical human immunodeficiency virus (HIV) infection. Antiretroviral drugs are being widely used before and during pregnancy, although these drugs can have possible adverse effects on the fetus and newborn. In this context, we report a unique case of X-linked severe combined immunodeficiency in a neonate vertically exposed to HIV.

引用

页码：187 / 189

页数：3

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