Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor γ Agonist In Vivo

被引：15
|
作者：
Yamamoto, Atsuki [1 ]
Kakuta, Hiroki [1 ]
Miyachi, Hiroyuki [1 ]
Sugimoto, Yukio [1 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008530, Japan
来源：
PPAR RESEARCH | 2011年 / 2011卷
关键词：
NECROSIS-FACTOR-ALPHA; PPAR-GAMMA; NITRIC-OXIDE; DOWN-REGULATION; RXR AGONISTS; PAW EDEMA; CELLS; INFLAMMATION; HETERODIMERS; EXPRESSION;
D O I：
10.1155/2011/840194
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Peroxisome proliferator-activated receptor gamma (PPAR gamma) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs). It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice. Therefore, it is suggested that the endogenous RXR ligand is involved in the PPAR gamma agonist-induced anti-inflammatory effect. However, the participation of the RXR ligand in the PPAR gamma-induced anti-inflammatory effect is unknown. Here, we investigated the influence of RXR antagonist on the anti-inflammatory effect of PPAR gamma agonist pioglitazone in carrageenan test. In addition, we also examined the influence of PPAR antagonist on the anti-inflammatory effect induced by RXR agonist NEt-3IP. The RXR antagonist suppressed the antiedema effect of PPAR gamma agonist. In addition, the anti-inflammatory effect of RXR agonist was suppressed by PPAR gamma antagonist. PPAR gamma agonist-induced anti-inflammatory effects were reversed by the RXR antagonist. Thus, we showed that the endogenous RXR ligand might contribute to the PPAR gamma agonist-induced anti-inflammatory effect.
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页数：8
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