Hepatic gene expression and prediction of therapy response in chronic hepatitis C patients

被引：14
|
作者：
Selzner, Nazia [1 ]
Chen, Limin [2 ]
Borozan, Ivan [2 ]
Edwards, Aled [2 ]
Heathcote, E. Jenny [3 ]
McGilvray, Ian [1 ,2 ]
机构：
[1] Univ Toronto, Univ Hlth Network, Multiorgan Transplant Program, Toronto Gen Hosp 11C 1250, Toronto, ON M5G 2N2, Canada
[2] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5G 2N2, Canada
[3] Univ Toronto, Dept Med, Toronto, ON M5G 2N2, Canada
来源：
JOURNAL OF HEPATOLOGY | 2008年 / 48卷 / 05期
关键词：
chronic hepatitis C infection; predictors of therapy response; genomics;
D O I：
10.1016/j.jhep.2008.02.010
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Chronic hepatitis C (HCV) infection remains a major health problem worldwide. The current standard of care is a combination of pegylated interferon-alpha and ribavirin. Considering the length of antiviral therapy, as well as its side effects and costs, accurate prediction of treatment response prior to initiation of treatment is critical. In addition to viral, demographic and environmental factors, host genetic diversity is believed to contribute to the spectrum of clinical outcomes of chronic HCV. The development of high-throughput technologies provides opportunities to define patterns of gene expression that are associated with certain disease outcomes and/or response to therapy. This article reviews genomics-based predictors of pre-treatment response to antiviral therapy. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V.. All rights reserved.
引用
收藏
页码：708 / 713
页数：6
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