STEM CELLS IN BRAIN TUMOR DEVELOPMENT

被引：13
|
作者：
Llaguno, Sheila R. Alcantara [1 ]
Chen, Yuntao [1 ]
Mckay, Renee M. [1 ]
Parada, Luis F. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA
来源：
CANCER AND DEVELOPMENT | 2011年 / 94卷
关键词：
ADULT HIPPOCAMPAL NEUROGENESIS; CATENIN/TCF SIGNALING PATHWAY; HUMAN GLIOBLASTOMA-MULTIFORME; NEURAL STEM/PROGENITOR CELLS; SUPPRESSOR MOUSE MODELS; GROWTH-FACTOR RECEPTOR; HIGH-GRADE GLIOMA; IN-VIVO; SELF-RENEWAL; SUBVENTRICULAR ZONE;
D O I：
10.1016/B978-0-12-380916-2.00002-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gliomas are highly infiltrative and aggressive brain tumors that are resistant to conventional therapies. Recent studies have implicated neural stem cells (NSCs) in brain tumor initiation and development. Subpopulations of stem-like cancer cells have also been isolated from brain tumors, and are purported to be important mediators of malignant behavior and therapeutic resistance. Similar signaling pathways may be operative in both neural and cancer stem cells, suggesting that neural developmental systems may provide important clues on brain tumorigenesis. Transcriptional regulators such as microRNAs may also contribute to NSC and brain tumor development. Understanding the biology of neural and cancer stem cells and their regulatory mechanisms may directly impact current efforts for more directed therapeutics against these highly aggressive tumors.
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页码：15 / 44
页数：30
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