Transforming growth factor β activity in human thyroid gland disorders

被引：0
|
作者：
Stoika, RS [1 ]
Lukavetsky, AV
Yakymovych, IA
Yakymovych, MY
Stasyk, TV
Lukavetsky, NA
机构：
[1] Natl Acad Sci Ukraine, AV Palladin Biochem Inst, Div Regulatory Cell Syst, UA-290005 Lvov, Ukraine
[2] Lviv State Med Univ, UA-290010 Lvov, Ukraine
来源：
EXPERIMENTAL ONCOLOGY | 1999年 / 21卷 / 01期
关键词：
transforming growth factor beta; human thyroid gland disorders;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The activity of transforming growth factor beta (TGF-beta) was compared in blood serum of healthy donors and patients with thyroid gland disorders: multinodular goiter, Graves' disease, thyroid cancer, and autoimmune thyroiditis. TGF-beta activity was determined using analytical tests which are based on the ability of this cytokine to regulate differentially the anchorage-independent proliferation of the cells of mesenchymal and epithelial origin. The activity of TGF-beta in blood serum of the patients was found to be increased with a maximal change in the patients with autoimmune thyroiditis and thyroid cancer. Taking into account that TGF-beta is a potent natural immunosupressor, one may suggest that the increased activity of this cytokine could play an important role in this thyroid gland disorders.
引用
收藏
页码：44 / 48
页数：5
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