Synthesis and antimicrobial activities of some new benzodiazepines and benzothiazepines

被引：0
|
作者：
Tirlapur, Vijay Kumar [1 ]
Veershetty, C. H. [1 ]
Udupi, R. H. [2 ]
Prasad, Y. Rejandra [3 ]
机构：
[1] Karnataka Coll Pharm, Post Grad Ctr, Bidar 585403, India
[2] NET Pharm Coll, Dept Pharmaceut Chem, Raichur 584103, India
[3] Andhra Univ, Dept Pharmaceut Sci, Visakhapatnam 530013, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2008年 / 17卷 / 04期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Claisen-Schmidt condensation of p-methoxy acetophenone I with aromatic aldehydes in ethanol in presence of strong alkali gave 1-(4-methoxy phenyl)-3-phenyl prop-en-1 ones (2a-d). Reactions of (2a-d) with orthophenylinediamine and orthoaminothiophenol in abs alcohol gave 3-(4-methoxyphenyl)-2-phenyl-2,3 dihydro-1H-1,5 benzodiazepines (3a-d) and 3-(4-methoxyphenyl)-2-phenyl-2,3 dihydro-1H-1.5 benzothiazepines (4a-d). All newly synthesized compounds were characterized by using IR, (1)H NMR and mass spectral studies and these compounds were evaluated for their antimicrobial activities.
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页码：351 / 354
页数：4
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