Age-specific modulation of genes involved in lipid and cholesterol homeostasis by dietary zinc

被引：3
|
作者：
Mazzatti, Dawn J. [1 ]
Mocchegiani, Eugenio [2 ]
Powell, Jonathan R. [1 ]
机构：
[1] Unilever Corp Res, Sharnbrook MK44 1LQ, Beds, England
[2] Italian Natl Res Ctr Ageing, Nutr Immun & Ageing Sect, Ancona, Italy
来源：
REJUVENATION RESEARCH | 2008年 / 11卷 / 02期
关键词：
D O I：
10.1089/rej.2007.0610
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The association between zinc status and lipid-related metabolic diseases, such as coronary heart disease, has produced conflicting results. Since heterogeneity of the adult population- or inter-individual variation-may impact on response to dietary zinc, nutritional genomic approaches were used to investigate the impact of age on zinc-regulated gene expression in lymphocytes. Many genes involved in lipid and cholesterol homeostasis were found to be differentially regulated by zinc in an age-dependent manner. Additionally, the individual genes affected and the extent of differential regulation varied with respect to donor age, suggesting that the age-related phenotype may alter zinc action.
引用
收藏
页码：281 / 285
页数：5
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