Arborcandins A, B, C, D, E and F, novel 1,3-β-glucan synthase inhibitors:: Physico-chemical properties and structure elucidation

被引：5

作者：

Ohyama, T

Iwadate-Kurihara, Y

Ishikawa, T

Miyakoshi, S

Hamano, K

Inukai, M

机构：

[1] Sankyo Co Ltd, Lead Discovery Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

[2] Sankyo Co Ltd, Exploratory Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

[3] Sankyo Co Ltd, Biomed Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 12期

关键词：

D O I：

10.7164/antibiotics.56.1024

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Arborcandins A, 13, C, D, E and F, which possess potent 1,3-beta-glucan synthase inhibitory activity, were isolated from the cultured broth of a filamentous fungus, strain SANK 17397. The structures of arborcandins A, B, C, D, E and F were elucidated by a combination of NMR and mass spectrometry, and established to be novel cyclic peptides containing uncommon amino acid residues.

引用

页码：1024 / 1032

页数：9

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