Anti-allergic prenylated flavonoids from the roots of Sophora flavescens

被引：21

作者：

Quan, Wenying ^{[1
]}

Lee, Hee Ju ^{[2
]}

Kim, Chul Young ^{[2
]}

Noh, Chu Won

Um, Byung Hun ^{[2
]}

Oak, Min-Ho ^{[1
]}

Kim, Kyeong-Man ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Pharmacol, Coll Pharm, Drug Dev Res Ctr, Kwangju 500757, South Korea

[2] KIST Gangneung Inst, Nat Prod Res Ctr, Kangnung, Gangwon Do, South Korea

来源：

PLANTA MEDICA | 2008年 / 74卷 / 02期

关键词：

Sophora flavescens; Leguminosae; anti-allergic activity; prenylated flavonoids;

D O I：

10.1055/s-2008-1034285

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids (11 -8) responsible for the in vitro anti-allergic activity. Among them, kushenol N (3), sophoraflavanone G (6), and leachianone A (7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC50 values ranging from 15 to 30 mu M.

引用

页码：168 / 170

页数：3

共 50 条

[21] Antipsoriatic activity of flavonoids isolated from the roots of Sophora flavescens Aiton
Kim, Byung Hak
Kim, Tae-Yoon
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2012, 66 (04) : AB170 - AB170
[22] Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens
Jin, Jeong Ho
Kim, Ju Sun
Kang, Sam Sik
Son, Kun Ho
Chang, Hyun Wook
Kim, Hyun Pyo
JOURNAL OF ETHNOPHARMACOLOGY, 2010, 127 (03) : 589 - 595
[23] α-Glucosidase inhibition by prenylated and lavandulyl compounds from Sophora flavescens roots and in silico analysis
Kim, Jang Hoon
Cho, Chong Woon
Kim, Hyo Young
Kim, Kyung Tae
Choi, Gug-Seoun
Kim, Hyeong-Hwang
Cho, In Sook
Kwon, Sun Jung
Choi, Seung-Kook
Yoon, Ju-Yeon
Yang, Seo Young
Kang, Jong Seong
Kim, Young Ho
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 102 : 960 - 969
[24] Selective Inhibition of Prenylated Flavonoids from Sophora flavescens against BACE1 and Cholinesterases
Jung, Hyun Ah
Yokozawa, Takako
Kim, Byung-Woo
Jung, Jee H.
Choi, Jae Sue
AMERICAN JOURNAL OF CHINESE MEDICINE, 2010, 38 (02): : 415 - 429
[25] Low Density Lipoprotein (LDL)-Antioxidant Flavonoids from Roots of Sophora flavescens
Jeong, Tae-Sook
Ryu, Young Bae
Kim, Hoi Young
Curtis-Long, Marcus John
An, So Jin
Lee, Jin Hwan
Lee, Woo Song
Park, Ki Hun
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (11) : 2097 - 2102
[26] A new cytotoxic prenylated chalcone from Sophora flavescens
Lee, Jae Hyeok
Baek, Nam-In
Kim, Sung-Hoon
Park, Hee Wook
Yang, Jae Heon
Lee, Jeong Joo
Kim, Seong Jin
Jeong, Seung il
Oh, Chan-Ho
Lee, Kyu-Hee
Kim, Dae Keun
ARCHIVES OF PHARMACAL RESEARCH, 2007, 30 (04) : 408 - 411
[27] Glycosidase inhibitory flavonoids from Sophora flavescens
Kim, JH
Ryu, YB
Kang, NS
Lee, BW
Heo, JS
Jeong, IY
Park, KH
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (02) : 302 - 305
[28] Prenylated Flavonoids Isolated from the Root of Sophora flavescens as Potent Antifungal Agents against Botrytis cinerea
An, Jun-Xia
Wang, Rui
Li, An-Ping
Zhang, Wen
Nan, Zhibiao
Jiang, Wei-Qi
Zhang, Shao-Yong
Zhang, Zhi-Jun
Luo, Xiong-Fei
Liang, Hong-Jie
Liu, Ying-Qian
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (36) : 19618 - 19628
[29] Antibacterial and antiandrogen flavonoids from Sophora flavescens
Kuroyanagi, M
Arakawa, T
Hirayama, Y
Hayashi, T
JOURNAL OF NATURAL PRODUCTS, 1999, 62 (12): : 1595 - 1599
[30] Prenylated Flavonoids Isolated from the Root of Sophora flavescens as Potent Antifungal Agents against Botrytis cinerea
An, Jun-Xia
Wang, Rui
Li, An-Ping
Zhang, Wen
Nan, Zhibiao
Jiang, Wei-Qi
Zhang, Shao-Yong
Zhang, Zhi-Jun
Luo, Xiong-Fei
Liang, Hong-Jie
Liu, Ying-Qian
Journal of Agricultural and Food Chemistry, 1600, 72 (36): : 19618 - 19628

← 1 2 3 4 5 →