Are Beta Blockers New Potential Anticancer Agents?

被引:17
|
作者
Akbar, Shahid [1 ]
Alsharidah, Mansour Saleh [2 ]
机构
[1] Qassim Univ, Coll Pharm, Dept Pharmacol, Buraydah, Saudi Arabia
[2] Qassim Univ, Coll Med, Dept Physiol, Buraydah, Saudi Arabia
关键词
Beta; blockers; adrenoceptors; anticancer; breast; ovarian; pancreatic; prostate; CONVERTING ENZYME-INHIBITORS; PANCREATIC-CANCER CELLS; ENDOTHELIAL GROWTH-FACTOR; PROMOTES TUMOR-GROWTH; BREAST-CANCER; KAPPA-B; ADRENERGIC-RECEPTORS; CARCINOMA-CELLS; RISK; NOREPINEPHRINE;
D O I
10.7314/APJCP.2014.15.22.9567
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
beta-Blockers have been one of the most widely used and versatile drugs for the past half a century. A new potential for their use as anti-cancer drugs has emerged in the past few years. Various retrospective case control studies have been suggestive that use of beta-blockers before the diagnosis of cancer could have preventive and protective effects against non-small cell lung carcinoma, melanoma, and breast, pancreatic and prostate cancers. Experimental and clinical observations are still inconclusive with some inconsistent findings. However, indications are pointing toward a positive role of some beta-blockers against certain forms of cancers. This mini review is an effort to present the up to date published results of case-control studies and experimental findings.
引用
收藏
页码:9567 / 9574
页数:8
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