hENT1 RNA and Protein in Combination May Act as Predictive Biomarkers for Survival for Patients Treated With Adjuvant Gemcitabine in Pancreatic Cancer

被引:0
|
作者
Hale, J. [1 ]
Evans, A. [1 ]
Aughton, K. [1 ]
Elander, N. O. [1 ,2 ]
Ghaneh, P. [1 ]
Neoptolemos, J. P. [3 ]
Jackson, R. [1 ]
Cox, T. F. [1 ]
Campbell, F. [1 ]
Halloran, C. M. [1 ]
Mackey, J. R. [4 ,5 ]
Scarfe, A. G. [4 ,5 ]
Valle, J. W. [6 ]
Carter, R. [7 ]
Cunningham, D. [8 ,9 ]
Tebbutt, N. C. [10 ]
Goldstein, D. [11 ,12 ]
Shannon, J. [13 ,14 ]
Glimelius, B. [15 ]
Deakin, M. [16 ]
Charnley, R. M. [17 ]
Anthoney, A. [18 ]
Lerch, M. M. [19 ]
Mayerle, J. [19 ,20 ]
Costello, E. [1 ]
Palmer, D. H. [1 ]
Buechler, M. W. [3 ]
Greenhalf, W. [1 ]
机构
[1] Univ Liverpool, Liverpool Canc Trials Unit, Liverpool, Merseyside, England
[2] Linkoping Univ, Dept Oncol, Linkoping, Sweden
[3] Heidelberg Univ, Dept Surg, Heidelberg, Germany
[4] Cross Canc Inst, Edmonton, AB, Canada
[5] Univ Alberta, Edmonton, AB, Canada
[6] Univ Manchester, Christie NHS Fdn Trust, Manchester, Lancs, England
[7] Glasgow Royal Infirm, Glasgow, Lanark, Scotland
[8] Royal Marsden Natl Hlth Serv NHS Fdn Trust, London, England
[9] Royal Marsden Natl Hlth Serv NHS Fdn Trust, Surrey, England
[10] Austin Hlth, Melbourne, Vic, Australia
[11] Univ New South Wales, Prince Wales Hosp, Sydney, NSW, Australia
[12] Univ New South Wales, Sch Clin, Sydney, NSW, Australia
[13] Nepean Canc Ctr, Kingswood, NSW, Australia
[14] Univ Sydney, Sydney, NSW, Australia
[15] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden
[16] North Staffs Univ Hosp, Stoke On Trent, Staffs, England
[17] Freeman Rd Hosp, Newcastle Upon Tyne, Tyne & Wear, England
[18] St James Univ Hosp, Leeds, W Yorkshire, England
[19] Univ Med Greifswald, Dept Med A, Greifswald, Germany
[20] Klinikum LMU Munchen Grosshadern, Med Klin & Poliklin 2, Munich, Germany
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:1436 / 1437
页数:2
相关论文
共 50 条
  • [31] Putative Predictive Biomarkers of Survival in Patients with Metastatic Pancreatic Adenocarcinoma Treated with Gemcitabine and Ganitumab, an IGF1R Inhibitor
    McCaffery, Ian
    Tudor, Yanyan
    Deng, Hongjie
    Tang, Rui
    Suzuki, Samuel
    Badola, Sunita
    Kindler, Hedy L.
    Fuchs, Charles S.
    Loh, Elwyn
    Patterson, Scott D.
    Chen, Li
    Gansert, Jennifer L.
    CLINICAL CANCER RESEARCH, 2013, 19 (15) : 4282 - 4289
  • [32] Cytidine Deaminase (CDA) Transcript Analysis Complements hENT1 Protein Staining in Predicting Gemcitabine Response in the ESPAC-3 Pancreatic Cancer Cohort
    Elander, N.
    Aughton, K.
    Ghaneh, P.
    Neoptolemos, J. P.
    Costello, E.
    Palmer, D.
    Cox, T.
    Campbell, F.
    Garner, E.
    Evans, A. S.
    Rimmer, N.
    Halloran, C.
    Buechler, M. W.
    Greenhalf, W.
    PANCREAS, 2015, 44 (08) : 1371 - 1371
  • [33] Human equilibrative nucleoside transporter 1 (hENT1) protein is associated with short survival in resected ampullary cancer
    Santini, D.
    Perrone, G.
    Vincenzi, B.
    Lai, R.
    Cass, C.
    Alloni, R.
    Rabitti, C.
    Antinori, A.
    Vecchio, F.
    Morini, S.
    Magistrelli, P.
    Coppola, R.
    Mackey, J. R.
    Tonini, G.
    ANNALS OF ONCOLOGY, 2008, 19 (04) : 724 - 728
  • [34] The expression of human equilibrative nucleoside transporter 1 (hENT1) is associated with overall survival in advanced biliary tract carcinoma (BTC) treated with gemcitabine
    Murata, Akihiro
    Amano, Ryousuke
    Kimura, Kenjiro
    Yamada, Nobuya
    Nakata, Bunzo
    Nagahara, Hisashi
    Noda, Eiji
    Kubo, Naoshi
    Tanaka, Hiroaki
    Muguruma, Kazuya
    Yashiro, Masakazu
    Maeda, Kiyoshi
    Ohira, Masaichi
    Ishikawa, Tetsurou
    Hirakawa, Kosei
    CANCER RESEARCH, 2012, 72
  • [35] hENT-1 Expression in Circulating Tumor Cells is a Potential Predictive Biomarker of Gemcitabine Outcome in Pancreatic Cancer Patients
    Ma, Y. S.
    Zhao, X. D.
    Tian, X. D.
    Yang, Y. M.
    PANCREAS, 2019, 48 (10) : 1483 - 1484
  • [36] Adenoviral-mediated overexpression of human equilibrative nucleoside transporter 1 (hENT1) enhances gemcitabine response in human pancreatic cancer
    Perez-Torras, Sandra
    Garcia-Manteiga, Jose
    Mercade, Elena
    Casado, F. Javier
    Carbo, Neus
    Pastor-Anglada, Marcal
    Mazo, Adela
    BIOCHEMICAL PHARMACOLOGY, 2008, 76 (03) : 322 - 329
  • [37] Human Equilibrative Nucleoside Transporter 1 (hENT1) Predicts the Asian Patient Response to Gemcitabine-Based Chemotherapy in Pancreatic Cancer
    Xiao, Jian-Chun
    Zhang, Tai-Ping
    Zhao, Yu-Pei
    HEPATO-GASTROENTEROLOGY, 2013, 60 (122) : 258 - 262
  • [38] Prognostic Role of hENT1 and RRM1 in Patients with Advanced Pleural Mesothelioma Treated with Second Line Gemcitabine Based Regimens
    Cardona, Andres
    Arrieta, Oscar
    Rojas, Leonardo
    Corrales, Luis
    Wills, Beatriz
    Oblitas, George
    Bacon, Ludwing
    Martin, Claudio
    Cuello, Mauricio
    Mas, Luis
    Vargas, Carlos
    Carranza, Hernan
    Otero, Jorge
    Perez, Maria
    Gonzalez, Lisde
    Chirinos, Luis
    Rosell, Rafael
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) : S1366 - S1367
  • [39] Human equilibrative nucleoside transporter 1 (hENT1): Do we really have a new predictive biomarker of chemotherapy outcome in pancreatic cancer patients?
    Mohelnikova-Duchonova, Beatrice
    Melichar, Bohuslav
    PANCREATOLOGY, 2013, 13 (06) : 558 - 563
  • [40] The high stromal SPARC expression is independently associated with poor survival of patients with resected pancreatic ductal adenocarcinoma treated with adjuvant gemcitabine in combination with S-1 or adjuvant gemcitabine alone
    Shintakuya, Ryuta
    Kondo, Naru
    Murakami, Yoshiaki
    Uemura, Kenichiro
    Nakagawa, Naoya
    Okano, Keisuke
    Takahashi, Shinya
    Sueda, Taijiro
    PANCREATOLOGY, 2018, 18 (02) : 191 - 197