Synthesis of 2',3'-dideoxypurinenucleosides via the palladium catalyzed reduction of 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-beta-D-xylofuranosyl)purine derivatives

被引：15

作者：

Shiragami, H ^{[1
]}

Amino, Y ^{[1
]}

Honda, Y ^{[1
]}

Arai, M ^{[1
]}

Tanaka, Y ^{[1
]}

Iwagami, H ^{[1
]}

Yukawa, T ^{[1
]}

Izawa, K ^{[1
]}

机构：

[1] AJINOMOTO CO INC,CENT RES LABS,KAWASAKI KU,KAWASAKI,KANAGAWA 210,JAPAN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 1-3期

关键词：

D O I：

10.1080/07328319608002368

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Practical method to produce 2',3'-dideoxypurinenucleosides from 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-beta-D-xylofuranosyl)purines (1) was developed. High ratio of 2',3 '-dideoxynucleoside to 3'-deoxyribonucleoside was obtained by Selecting the reaction conditions (solvent, pH and/or base), or changing 2'-acyloxy leaving group. The reaction mechanism was studied by deuteration experiments of 1a and 1-(3,5-di-O-acetyl-2-bromo-2-deoxy-beta-D-ribofuranosyl)thymine (12).

引用

页码：31 / 45

页数：15

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