Ligand-Free CuI-Catalyzed Chemoselective S-Arylation of 2-Mercaptobenzimidazole with Aryl Iodides

被引：7

作者：

Tan, Bryan Yong-Hao ^{[2
]}

Teo, Yong-Chua ^{[1
,2
]}

机构：

[1] Nanyang Technol Univ, Natl Inst Educ, Nat Sci & Sci Educ, 1 Nanyang Walk, Singapore 637616, Singapore

[2] Nanyang Technol Univ, Natl Inst Educ, Nat Sci & Sci Educ, 1 Nanyang Walk, Singapore 637616, Singapore

来源：

SYNLETT | 2018年 / 29卷 / 15期

关键词：

2-mercaptobenzimidazole; ligand-free; S-arylation; copper(I) iodide; chemoselective; REVERSE-TRANSCRIPTASE INHIBITOR; EFFICIENT COPPER CATALYST; N-ARYLATION; HALIDES; THIOLS; THIAZOLOBENZIMIDAZOLE; AMIDATION; PHENOLS; ULLMANN;

D O I：

10.1055/s-0037-1610655

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and efficient strategy for the chemoselective C-S cross-coupling of 2-mercaptobenzimidazole derivatives with a range of substituted aryl iodides is described. Under the optimized conditions of 5 mol% CuI and 100 degrees C, a variety of S-arylated products were obtained in good to excellent yields (up to 92 %) without the need for assisting ligands.

引用

页码：2056 / 2060

页数：5

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