Can we avoid the toxicity of chemotherapy in elderly cancer patients?

被引：25

作者：

Feliu, Jaime ^{[1
]}

Heredia-Soto, Victoria ^{[1
]}

Girones, Regina ^{[2
]}

Jimenez-Munarriz, Beatriz ^{[3
]}

Saldana, Juana ^{[4
]}

Guillen-Ponce, Carmen ^{[5
]}

Molina-Garrido, M. J. ^{[6
]}

机构：

[1] Hosp Univ La Paz, Dept Med Oncol, CIBERONC, Madrid, Spain

[2] Hosp Lluis Alcanyis, Dept Med Oncol, Valencia, Spain

[3] Hosp Univ Clara Campal, Dept Med Oncol, Madrid, Spain

[4] Inst Catalan Oncol, Dept Med Oncol, Barcelona, Spain

[5] Hosp Univ Ramon & Cajal, Dept Med Oncol, Madrid, Spain

[6] Hosp Virgen de la Luz, Dept Med Oncol, Cuenca, Spain

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2018年 / 131卷

关键词：

Cancer; Elderly; Chemotherapy; Risk score; Toxicity; Geriatric assessment; COMPREHENSIVE GERIATRIC ASSESSMENT; CELL LUNG-CANCER; OLDER PATIENTS; INTERNATIONAL-SOCIETY; TREATMENT DECISIONS; COLORECTAL-CANCER; FUNCTIONAL STATUS; PROSTATE-CANCER; CLINICAL-TRIALS; WEIGHT-LOSS;

D O I：

10.1016/j.critrevonc.2018.08.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although approximately 50% of cancer patients are 70 years of age or older, cancer treatment in the elderly remains a therapeutic challenge. The elderly form a very heterogeneous group in relation to their general health state, degree of dependence, comorbidities, performance status, physical reserve and geriatric situation, for which therapeutic decisions must be made in an individualized manner. In addition, changes in pharmacokinetics and pharmacodynamics of the drugs occur with age, as well as the tolerance of the tissues, leading to a narrowing of the therapeutic margin and an increase in toxicity. In the general population, Performace Status (PS) has traditionally been used to estimate tolerance to chemotherapy, but in the elderly population it is not useful. In this review we summarize the current knowledge about the pharmacology of antineoplastic drugs in the elderly and the tools available to help us identify risk of chemotherapy toxicity in these patients.

引用

页码：16 / 23

页数：8

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