Mesenchymal stem cells: Cancer promoting effects or tumor suppression - A current overview

被引：2
|
作者：
Scherzad, Agmal [1 ]
Taeger, Johannes [1 ]
Gehrke, Thomas Eckhard [1 ]
Hagen, Rudolf [1 ]
Kleinsasser, Norbert [1 ]
Hackenberg, Stephan [1 ]
机构：
[1] Julius Maximilians Univ Wurzburg, Klin & Poliklin Hals Nasen & Ohrenkrankheiten Pla, Josef Schneider Str 11, D-97080 Wurzburg, Germany
来源：
LARYNGO-RHINO-OTOLOGIE | 2018年 / 97卷 / 10期
关键词：
mesenchymal stem cells; soluble mediators; immune suppression; neoangiogenesis; cancer stroma; STROMAL CELLS; MYOCARDIAL-INFARCTION; INTERNATIONAL-SOCIETY; PROGENITOR CELLS; IN-VITRO; GROWTH; ADHESION; THERAPY; LUNG; EXPRESSION;
D O I：
10.1055/a-0650-4673
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The multimodal treatment of cancer deals with cancer cells as well as with the cancer surrounding stroma. This stroma contains non-malignant cells like fibroblasts, immune cells as well as mesenchymal stem cells (MSC). MSC have the ability to migrate towards cancer tissue. In the current literature the impact of MSC on cancer cells is discussed divergently. The majority of the current publications reveal an induction of cancer progression by MSC. Four main processes namely the secretion of soluble factors and cell-cell contact, the transdifferentiation of MSC into carcinoma associated fibroblasts, the improvement of neoangiogenesis and the induction of immune suppression are responsible for cancer progression. This publication gives an overview on the current literature.
引用
收藏
页码：678 / 687
页数：10
相关论文
共 50 条
  • [21] Mesenchymal Stem Cells and Cancer Steam Cells: An Overview of Tu-mor-Mesenchymal Stem Cell Interaction for Therapeutic Interventions
    Montazersaheb, Soheila
    Fathi, Ezzatollah
    Mamandi, Ayoub
    Farahzadi, Raheleh
    Heidari, Hamid Reza
    CURRENT DRUG TARGETS, 2022, 23 (01) : 60 - 71
  • [22] An overview of current research on cancer stem cells: a bibliometric analysis
    Zhang, Xueyang
    Du, Wenbo
    Huang, Xizhi
    Zhong, Haoting
    Hu, Ning
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2024, 26 (10): : 2466 - 2478
  • [23] Mesenchymal stem cells as a double-edged sword in suppression or progression of solid tumor cells
    Norozi, Fatemeh
    Ahmadzadeh, Ahmad
    Shahrabi, Saeid
    Vosoughi, Tina
    Saki, Najmaldin
    TUMOR BIOLOGY, 2016, 37 (09) : 11679 - 11689
  • [24] The effects of mesenchymal stem cells on the chemotherapy of colorectal cancer
    Wang, Meiqi
    Li, Jiannan
    Wang, Dongxin
    Xin, Ying
    Liu, Zhuo
    BIOMEDICINE & PHARMACOTHERAPY, 2023, 160
  • [25] Effects of Inflammatory Factors on Mesenchymal Stem Cells and Their Role in the Promotion of Tumor Angiogenesis in Colon Cancer
    Liu, Yan
    Han, Zhi-peng
    Zhang, Shan-shan
    Jing, Ying-ying
    Bu, Xin-xin
    Wang, Chen-yang
    Sun, Kai
    Jiang, Guo-cheng
    Zhao, Xue
    Li, Rong
    Gao, Lu
    Zhao, Qiu-dong
    Wu, Meng-chao
    Wei, Li-xin
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (28) : 25007 - 25015
  • [26] Effect of mesenchymal stem cells-derived exosomes on tumor microenvironment: Tumor progression versus tumor suppression
    Shojaei, Samaneh
    Hashemi, Seyed Mahmoud
    Ghanbarian, Hossein
    Salehi, Mohammad
    Mohammadi-Yeganeh, Samira
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (04) : 3394 - 3409
  • [27] How mesenchymal stem cells transform into adipocytes: Overview of the current understanding of adipogenic differentiation
    Liu, Shan-Shan
    Fang, Xiang
    Wen, Xin
    Liu, Ji-Shan
    Alip, Miribangvl
    Sun, Tian
    Wang, Yuan-Yuan
    Chen, Hong-Wei
    WORLD JOURNAL OF STEM CELLS, 2024, 16 (03): : 245 - 256
  • [28] Mesenchymal stem cells and breast tumor cells
    Martinez, Leandro M.
    Labovsky, Vivian
    Fernandez Vallone, Valeria Beatriz
    Bordenave, Horacio
    Feldman, Leonardo
    Alejandra Chasseing, Norma
    CLINICAL & EXPERIMENTAL METASTASIS, 2011, 28 (02) : 199 - 199
  • [29] Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells
    Kabashima-Niibe, Ayano
    Higuchi, Hajime
    Takaishi, Hiromasa
    Masugi, Yohei
    Matsuzaki, Yumi
    Mabuchi, Yo
    Funakoshi, Shinsuke
    Adachi, Masayuki
    Hamamoto, Yasuo
    Kawachi, Shigeyuki
    Aiura, Koichi
    Kitagawa, Yuko
    Sakamoto, Michiie
    Hibi, Toshifumi
    CANCER SCIENCE, 2013, 104 (02): : 157 - 164
  • [30] Proliferative Effects of Mesenchymal Stromal Cells on Neuroblastoma Cell Lines: Are They Tumor Promoting or Tumor Inhibiting?
    Doyle, Kathleen
    Sutter, Maria
    Rodriguez, Monica
    Hassan, Abd-Elrahman
    Kumar, Priyadarsini
    Brown, Erin
    JOURNAL OF PEDIATRIC SURGERY, 2024, 59 (08) : 1582 - 1590
12345