Mesenchymal stem cells: Cancer promoting effects or tumor suppression - A current overview

被引：2
|
作者：
Scherzad, Agmal [1 ]
Taeger, Johannes [1 ]
Gehrke, Thomas Eckhard [1 ]
Hagen, Rudolf [1 ]
Kleinsasser, Norbert [1 ]
Hackenberg, Stephan [1 ]
机构：
[1] Julius Maximilians Univ Wurzburg, Klin & Poliklin Hals Nasen & Ohrenkrankheiten Pla, Josef Schneider Str 11, D-97080 Wurzburg, Germany
来源：
LARYNGO-RHINO-OTOLOGIE | 2018年 / 97卷 / 10期
关键词：
mesenchymal stem cells; soluble mediators; immune suppression; neoangiogenesis; cancer stroma; STROMAL CELLS; MYOCARDIAL-INFARCTION; INTERNATIONAL-SOCIETY; PROGENITOR CELLS; IN-VITRO; GROWTH; ADHESION; THERAPY; LUNG; EXPRESSION;
D O I：
10.1055/a-0650-4673
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The multimodal treatment of cancer deals with cancer cells as well as with the cancer surrounding stroma. This stroma contains non-malignant cells like fibroblasts, immune cells as well as mesenchymal stem cells (MSC). MSC have the ability to migrate towards cancer tissue. In the current literature the impact of MSC on cancer cells is discussed divergently. The majority of the current publications reveal an induction of cancer progression by MSC. Four main processes namely the secretion of soluble factors and cell-cell contact, the transdifferentiation of MSC into carcinoma associated fibroblasts, the improvement of neoangiogenesis and the induction of immune suppression are responsible for cancer progression. This publication gives an overview on the current literature.
引用
收藏
页码：678 / 687
页数：10
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