AN UPDATE OVERVIEW OF RECENT ADVANCES ON FORMULATION DEVELOPMENT FOR COLON TARGETING

In targeted drug delivery systems, there is one of the most important drug delivery systems is colon targeting drug delivery system. This system is mainly used in the treatment of diseases like colonic cancer, ulcerative colitis, Crohn's disease. For local treatment of various bowel diseases colon is highly desirable. For the systemic action of nonpeptide drugs i.e., cardiovascular and antiasthmatic agents and protein-peptide drugs such as insulin, calcitonin, colon targeting is apparently useful. There are various approaches that have been proposed for targeted colon delivery; they include the pH, pressure controlled, time-controlled, microflora, osmotic controlled, and multi-particulates and novel techniques. The carriers used in this system are microsphere, synthetic polymers, liposomes and nanoparticles, matrix tablets and compression coated tablets etc.