Synthesis of gold nanoparticles (AuNPs) with improved anti-diabetic, antioxidant and anti-microbial activity from Physalis minima

Background: Gold nanoparticles have come to prominence among noble metals due to their characteristics. Bio-transformed nanoparticles have a low toxicity and are biocompatible and ecologically benign. Physalis minima has been used in traditional medicine for its diuretic, laxative, and anti-inflammatory qualities since ancient times. Methods: Gold nanoparticles are formed when water gold metal ions interact with an aqueous plant extract of Physalis minima (Au NPs). Results: In a UV-visible spectrophotometer, the resulting Au NPs formed a broad surface peak at 546 nm. According to the FTIR data, the peaks represent flavonoids, phenols and polyphenols meaning that flavonoids, phenols, and polyphenols were utilised as the reducing agent to create gold nanoparticles. According to the XRD pattern, the synthesised gold nanoparticles are crystalline in nature in a cubic system, with average particle sizes of roughly 36 nm. Gold nanoparticles were evaluated and found to have a zeta potential of -20.5mv, suggesting that they were stable and suitable for biological uses. The morphology of gold nanoparticles was confirmed using microscopic imaging. Conclusion: This study looked at the anti-oxidant, anti-diabetic, and antibacterial properties of gold nanoparticles (Au NPs) made from Physalis minima, making it exceedingly promising for biological applications. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).