Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

被引：144

作者：

Melino, G. ^{[1
,2
]}

Gallagher, E. ^{[3
]}

Aqeilan, R. I. ^{[4
]}

Knight, R. ^{[2
]}

Peschiaroli, A. ^{[1
]}

Rossi, M. ^{[2
]}

Scialpi, F. ^{[1
]}

Malatesta, M. ^{[1
]}

Zocchi, L. ^{[1
]}

Browne, G. ^{[2
]}

Ciechanover, A. ^{[5
]}

Bernassola, F. ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, IDI IRCCS Biochem Lab, I-00133 Rome, Italy

[2] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England

[3] UCL Royal Free & Univ Coll Med Sch, London W1T 4JF, England

[4] Ohio State Univ, Columbus, OH 43210 USA

[5] Technion Israel Inst Technol, Canc & Vasc Biol Ctr, Rappaport Fac Med & Res Inst, IL-31096 Haifa, Israel

来源：

CELL DEATH AND DIFFERENTIATION | 2008年 / 15卷 / 07期

基金：

英国医学研究理事会;

关键词：

ubiquitin E3 ligase; apoptosis; JunB; p53 family members; Notch;

D O I：

10.1038/cdd.2008.60

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The HECT-type E3 ubiquitin ligase (E3) Itch is absent in the non-agouti-lethal 18H or Itchy mice, which develop a severe immunological disease, including lung and stomach inflammation and hyperplasia of lymphoid and hematopoietic cells. The involvement of Itch in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review aims to bring together a growing body of work exploring Itch-regulated biological processes, and to highlight recent discoveries on the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Our contribution is also an endeavor to correlate Itch substrate specificity with the pathological defects manifested by the mutant Itchy mice.

引用

页码：1103 / 1112

页数：10

共 50 条

[21] A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity
Miyazaki, K
Ozaki, T
Kato, C
Hanamoto, T
Fujita, T
Irino, S
Watanabe, K
Nakagawa, T
Nakagawara, A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 308 (01) : 106 - 113
[22] HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity
Nuro-Gyina, Patrick K.
Tang, Na
Guo, Hui
Yan, Chengkai
Zeng, Qiuming
Waldschmidt, Thomas J.
Zhang, Jian
JOURNAL OF IMMUNOLOGY, 2021, 207 (03): : 868 - 877
[23] CHARACTERIZATION OF A PLASMODIUM FALCIPARUM HECT E3 UBIQUITIN LIGASE
Singh, Brajesh Kumar
Su, Xin-zhuan
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2019, 101 : 470 - 470
[24] Molecular Evolution, Neurodevelopmental Roles and Clinical Significance of HECT-Type UBE3 E3 Ubiquitin Ligases
Ambrozkiewicz, Mateusz C.
Cuthill, Katherine J.
Harnett, Dermot
Kawabe, Hiroshi
Tarabykin, Victor
CELLS, 2020, 9 (11)
[25] The E3 ligase Itch in immune regulation and beyond
Aki, Daisuke
Zhang, Wen
Liu, Yun-Cai
IMMUNOLOGICAL REVIEWS, 2015, 266 (01) : 6 - 26
[26] HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets
Wong, Joyce Jing Yi
Pung, Yuh Fen
Sze, Newman Siu-Kwan
Chin, Keh-Chuang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (28) : 10735 - 10740
[27] High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy
M Rossi
B Rotblat
K Ansell
I Amelio
M Caraglia
G Misso
F Bernassola
C N Cavasotto
R A Knight
A Ciechanover
G Melino
Cell Death & Disease, 2014, 5 : e1203 - e1203
[28] High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy
Rossi, M.
Rotblat, B.
Ansell, K.
Amelio, I.
Caraglia, M.
Misso, G.
Bernassola, F.
Cavasotto, C. N.
Knight, R. A.
Ciechanover, A.
Melino, G.
CELL DEATH & DISEASE, 2014, 5 : e1203 - e1203
[29] Pharmaceutical Perspectives of HECT-TYPE Ubiquitin Ligase Smurf1
Cao, Yu
Zhang, Lingqiang
CURRENT PHARMACEUTICAL DESIGN, 2013, 19 (18) : 3226 - 3233
[30] Regulation of autoimmune disease by the E3 ubiquitin ligase Itch
Moser, Emily K.
Oliver, Paula M.
CELLULAR IMMUNOLOGY, 2019, 340

← 1 2 3 4 5 →