Removal of metabolite interference during liquid chromatography/tandem mass spectrometry using high-field asymmetric waveform ion mobility spectrometry

被引：34
|
作者：
Kapron, JT
Jemal, M
Duncan, G
Kolakowski, B
Purves, R
机构：
[1] Ionalyt Corp, Ottawa, ON K1A 0R6, Canada
[2] Bristol Myers Squibb Pharmaceut Res Inst, Bioanal & Discovery Analyt Sci, New Brunswick, NJ 08903 USA
来源：
RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2005年 / 19卷 / 14期
关键词：
D O I：
10.1002/rcm.2016
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of metabolite interference during liquid chromatography/tandem mass spectrometry (LC/MS/MS) analysis of an amine drug was investigated using FAIMS (high-Field Asymmetric waveform Ion Mobility Spectrometry). The selected reaction monitoring (SRM) transition used for the drug exhibited an interference due to in-source conversion of the N-oxide metabolite to generate an ion isobaric with the drug. The on-line FAIMS device removed the metabolite interference before entrance to the mass spectrometer. FAIMS was used to demonstrate the relative accuracy and precision of drug analysis even in the presence of a co-eluting metabolite that may undergo in-source conversion. Copyright (c) 2005 John Wiley & Sons, Ltd.
引用
收藏
页码：1979 / 1983
页数：5
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