A call for using natural compounds in the development of new antimalarial treatments-an introduction

被引:103
|
作者
Ginsburg, Hagai [1 ]
Deharo, Eric [2 ,3 ]
机构
[1] Hebrew Univ Jerusalem, Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel
[2] Univ Toulouse, UPS, Lab Pharmacochim Subst Nat & Pharmacophores Redox, UMR 152, F-31062 Toulouse 9, France
[3] Inst Rech Dev, UMR 152, Lima, Peru
关键词
PLASMODIUM-FALCIPARUM; PLANTS; PRODUCTS; MEDICINES; SYNERGY; AGENTS; ETHNOPHARMACOLOGY; ARTEMISININ; COMBINATION; FLAVONOIDS;
D O I
10.1186/1475-2875-10-S1-S1
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Natural compounds, mostly from plants, have been the mainstay of traditional medicine for thousands of years. They have also been the source of lead compounds for modern medicine, but the extent of mining of natural compounds for such leads decreased during the second half of the 20(th) century. The advantage of natural compounds for the development of drugs derives from their innate affinity for biological receptors. Natural compounds have provided the best anti-malarials known to date. Recent surveys have identified many extracts of various organisms (mostly plants) as having antiplasmodial activity. Huge libraries of fractionated natural compounds have been screened with impressive hit rates. Importantly, many cases are known where the crude biological extract is more efficient pharmacologically than the most active purified compound from this extract. This could be due to synergism with other compounds present in the extract, that as such have no pharmacological activity. Indeed, such compounds are best screened by cell-based assay where all potential targets in the cell are probed and possible synergies identified. Traditional medicine uses crude extracts. These have often been shown to provide many concoctions that deal better with the overall disease condition than with the causative agent itself. Traditional medicines are used by similar to 80 % of Africans as a first response to ailment. Many of the traditional medicines have demonstrable anti-plasmodial activities. It is suggested that rigorous evaluation of traditional medicines involving controlled clinical trials in parallel with agronomical development for more reproducible levels of active compounds could improve the availability of drugs at an acceptable cost and a source of income in malaria endemic countries.
引用
收藏
页数:7
相关论文
共 50 条
  • [41] Development of novel synthetic organic reactions: Synthesis of antitumor natural products and leading compounds for new pharmaceuticals
    Kita, Y
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2002, 122 (12): : 1011 - 1035
  • [42] Growth, development and natural resources: New evidence using a heterogeneous panel analysis
    Cavalcanti, Tiago V. de V.
    Mohaddes, Kamiar
    Raissi, Mehdi
    QUARTERLY REVIEW OF ECONOMICS AND FINANCE, 2011, 51 (04): : 305 - 318
  • [43] Synthetic study of biologically important nitrogen containing natural products: Development of new methodology and design of leading compounds for new pharmaceuticals
    Nakagawa, M
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2003, 123 (04): : 225 - 248
  • [44] DEVELOPMENT OF TECHNOLOGY FOR INTENSIFICATION OF OIL PRODUCTION USING EMULSION BASED ON NATURAL GASOLINE AND SOLUTIONS OF NITRITE COMPOUNDS
    Zholbassarova, A. T.
    Bayamirova, R. Y.
    Ratov, B. T.
    Khomenko, V. L.
    Togasheva, A. R.
    Sarbopeyeva, M. D.
    Tabylganov, M. T.
    Saduakasov, D. S.
    Gusmanova, A. G.
    Koroviaka, Ye. A.
    SOCAR PROCEEDINGS, 2024, (02): : 48 - 55
  • [45] Development of natural-based wound dressings impregnated with bioactive compounds and using supercritical carbon dioxide
    Dias, A. M. A.
    Braga, M. E. M.
    Seabra, I. J.
    Ferreira, P.
    Gil, M. H.
    de Sousa, H. C.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 408 (1-2) : 9 - 19
  • [46] Benchmark density functional theory calculations of 13C NMR chemical shifts of the natural antimalarial compounds with a new basis set 3z-S
    Semenov, Valentin A.
    Krivdin, Leonid B.
    INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, 2021, 121 (12)
  • [47] A NEW DEVELOPMENT IN LAPPING PLATES FOR SUPERFINE POLISHING OF SOFT MATERIALS USING DIAMOND COMPOUNDS
    SWAN, RJ
    INDUSTRIAL DIAMOND REVIEW, 1968, 28 (335): : 438 - &
  • [48] Ligand-based virtual screening and in silico design of new antimalarial compounds using nonstochastic and stochastic total and atom-type quadratic maps
    Marrero-Ponce, Y
    Iyarreta-Veitía, M
    Montero-Torres, A
    Romero-Zaldivar, C
    Brandt, CA
    Avila, PE
    Kirchgatter, K
    Machado, Y
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2005, 45 (04) : 1082 - 1100
  • [49] How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?
    Eric Guantai
    Kelly Chibale
    Malaria Journal, 10
  • [50] How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?
    Guantai, Eric
    Chibale, Kelly
    MALARIA JOURNAL, 2011, 10