Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances

被引：20
|
作者：
Bauer, LA
Black, DJ
Lill, JS
Garrison, J
Raisys, VA
Hooton, TM
机构：
[1] Univ Washington, Dept Pharm, Seattle, WA 98195 USA
[2] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA
[3] Univ Washington, Dept Pharm Serv, Seattle, WA 98195 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 04期
关键词：
D O I：
10.1128/AAC.49.4.1649-1651.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.
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页码：1649 / 1651
页数：3
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