Neurotrophin 3 and its receptor TrkC immunoreactivity in glucagon cells of buffalo pancreas

被引：5

作者：

Lucini, C ^{[1
]}

Costagliola, C ^{[1
]}

Borzacchiello, G ^{[1
]}

Castaldo, L ^{[1
]}

机构：

[1] Univ Naples Federico II, Dip Strutture Funz & Tecnol Biol, I-80137 Naples, Italy

来源：

ANATOMIA HISTOLOGIA EMBRYOLOGIA | 2003年 / 32卷 / 04期

关键词：

D O I：

10.1046/j.1439-0264.2003.00467.x

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Neurotrophin 3 (NT3), a member of the neurotrophin family, and its specific receptor tyrosine kinase C (TrkC) are involved in the differentiation, survival, and maintenance of many neuronal populations. Recently, NT3 and TrkC were also retained involved in the biology of non-neuronal tissues. In this study, we report the presence of NT3- and TrkC-immunoreactive cells in the endocrine pancreas of adult buffalos. They were usually distributed at the periphery of islets and showed intense immunoreactivity. By double immunohistochemical staining, NT3- and TrkC-IR resulted to be colocalized in glucagon immunoreactive cells. These findings suggest endocrine and/or autocrine roles of NT3 in pancreatic A cells.

引用

页码：253 / 256

页数：4

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