Relationship between the Severity of Inflammatory Changes in Chronic Sinusitis and the Level of Vitamin D before and after the FESS Procedure

被引:5
|
作者
Kalinczak-Gorna, Paulina [1 ]
Radajewski, Kamil [2 ]
Burduk, Pawel [1 ]
机构
[1] Nicolaus Copernicus Univ, Dept Otolaryngol Phoniatr & Audiol, Coll Med, PL-85168 Bydgoszcz, Poland
[2] Univ Hosp, Dept Otolaryngol Laryngol Oncol & Maxillofacial S, PL-85168 Bydgoszcz, Poland
关键词
chronic sinusitis; inflammation; vitamin D; FESS procedure;
D O I
10.3390/jcm10132836
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There have been a few reports confirming that vitamin D (VD3) deficiency increases inflammation in the paranasal sinuses. The work brings new information that, despite the presence of inflammation before surgery, patients with higher vitamin D levels had less inflammation, and this has been proven on three levels. We show that vitamin D levels clearly correlate with the severity of the disease in chronic sinusitis. These results have been confirmed in imaging studies (Lund MacKay scale), endoscopy (Lund-Kennedy scale) and in the SNOT 20 questionnaire. 40 patients suffering from chronic sinusitis were divided into two equal groups: group 1: with less severe radiological changes (10 or less points on the Lund-Mackay scale), group 2: with a more advanced form (>10 points). The relationship between VD3 and the severity of the disease (clinical and nasal endoscopy) was assessed. The mean VD3 level in patients in group 2 before surgery was lower (23.01 ng/mL) than in group 1 (28.02 ng/mL) (p < 0.05). They presented a higher degree of advanced changes in all the above scales, i.e., before the SNOT 20 procedure, the mean was: group 1: 30.33, group 2: 31.80 (p < NS); Lund-Kennedy: group 1: 3.21, group 2: 6.30 (p < 0.05). After surgery an increase in VD3 levels was observed in both study groups: in group 1 to the value of 37.98 ng/mL (p < 0.002) and in group 2 to 27.67 ng/mL (p < 0.004). Lower VD3 levels were found in patients with a higher stage of the disease. Reduction of inflammation increases the level of VD3 and reduces subjective and objective symptoms of chronic inflammation.
引用
收藏
页数:7
相关论文
共 50 条
  • [41] The relationship between serum vitamin D levels and the severity of headache in adult with migraine
    Younis, H.
    Omar, T.
    Daabis, A.
    JOURNAL OF HEADACHE AND PAIN, 2024, 25
  • [42] The Relationship between Symptom Severity and Low Vitamin D Levels in Patients with Schizophrenia
    Bulut, Suheyla Dogan
    Bulut, Serdar
    Atalan, Dicle Gorkem
    Berkol, Tonguc
    Gurcay, Eda
    Turker, Turker
    Aydemir, Cigdem
    PLOS ONE, 2016, 11 (10):
  • [43] RELATIONSHIP BETWEEN SEVERITY OF MIGRAINE AND VITAMIN D DEFICIENCY: A CASE CONTROL STUDY
    Rapisarda, L.
    Montisano, A. D.
    Sarica, A.
    Demonte, G.
    Tosto, F.
    Gambardella, A.
    Bono, F.
    JOURNAL OF HEADACHE AND PAIN, 2018, 19
  • [44] The Relationship Between Serum Vitamin D Levels and the Severity of Headache in Children with Migraine
    Gungor, Olcay
    Gungor, Sukru
    Acipayam, Can
    TRENDS IN PEDIATRICS, 2020, 1 (01): : 22 - 26
  • [45] Relationship between Vitamin D level and metabolic parameters in obese children and response to Vitamin D treatment
    Saymazlar, Dilek Damla
    Kara, Ozlem
    Orhaner, Betul Biner
    NORTHERN CLINICS OF ISTANBUL, 2022, 9 (03) : 235 - 240
  • [46] Correlation of severity of chronic obstructive pulmonary disease with serum vitamin-D level
    Baneen, Ummul
    Naseem, Sufia
    JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE, 2019, 8 (07) : 2268 - 2277
  • [47] The relationship between serum vitamin A and breast cancer staging before and after radiotherapy
    Matos, Andrea
    Nogueira, Carla
    Franca, Carlos
    Carvalho, Antonio
    Vieira, Sergio Lannes
    Penna, Antonio
    Ramalho, Andrea
    NUTRICION HOSPITALARIA, 2014, 29 (01) : 136 - 139
  • [48] THE RELATIONSHIP BETWEEN THE COTININE LEVEL IN URINE AND VITAMIN D IN THE UNIVERSITY STUDENTS
    Bakan, Ayse Berivan
    Uzun, Naim
    Arli, Senay Karadag
    Yildiz, Metin
    BELITUNG NURSING JOURNAL, 2020, 6 (06) : 214 - 219
  • [49] The relationship between vitamin D level and thyroid antibodies in primary hypothyroidism
    Salwa S. Hosny
    Maram M. M. Aboromia
    Nesma A. Ibrahim
    Doaa K. Abd El Halim
    The Egyptian Journal of Internal Medicine, 2019, 31 (2) : 164 - 170
  • [50] The relationship between serum vitamin D and chronic rhinosinusitis: A systematic review
    Stokes, Patrick J.
    Rimmer, Joanne
    AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 2016, 30 (01) : 23 - 28