Motor Neuron Transduction After Intracisternal Delivery of AAV9 in a Cynomolgus Macaque

被引：5

作者：

Bell, Peter ^{[1
]}

Hinderer, Christian ^{[1
]}

Louboutin, Jean-Pierre ^{[2
]}

Yu, Hongwei ^{[1
]}

Grant, Rebecca ^{[1
]}

Bote, Erin ^{[1
]}

Wilson, James M. ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Gene Therapy Program, Philadelphia, PA 19104 USA

[2] Univ W Indies, Dept Basic Med Sci, Sect Anat, Mona, Jamaica

来源：

HUMAN GENE THERAPY METHODS | 2015年 / 26卷 / 02期

关键词：

NONHUMAN-PRIMATES;

D O I：

10.1089/hgtb.2015.041

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The image shows a section of the lumbar spinal cord from a cynomolgus macaque that had received AAV9.CB.EGFP via the cisterna magna. Expression of GFP in multiple motor neurons is visible. Injection into the cerebrospinal fluid has been shown to be an effective route of vector administration for neuron transduction.

引用

页码：43 / 44

页数：2

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