Motor Neuron Transduction After Intracisternal Delivery of AAV9 in a Cynomolgus Macaque

被引：5
|
作者：
Bell, Peter [1 ]
Hinderer, Christian [1 ]
Louboutin, Jean-Pierre [2 ]
Yu, Hongwei [1 ]
Grant, Rebecca [1 ]
Bote, Erin [1 ]
Wilson, James M. [1 ]
机构：
[1] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Gene Therapy Program, Philadelphia, PA 19104 USA
[2] Univ W Indies, Dept Basic Med Sci, Sect Anat, Mona, Jamaica
来源：
HUMAN GENE THERAPY METHODS | 2015年 / 26卷 / 02期
关键词：
NONHUMAN-PRIMATES;
D O I：
10.1089/hgtb.2015.041
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The image shows a section of the lumbar spinal cord from a cynomolgus macaque that had received AAV9.CB.EGFP via the cisterna magna. Expression of GFP in multiple motor neurons is visible. Injection into the cerebrospinal fluid has been shown to be an effective route of vector administration for neuron transduction.
引用
收藏
页码：43 / 44
页数：2
相关论文
共 50 条
  • [1] Intracisternal delivery of AAV9 results in oligodendrocyte and motor neuron transduction in the whole central nervous system of cats
    T Bucher
    L Dubreil
    M-A Colle
    M Maquigneau
    J Deniaud
    M Ledevin
    P Moullier
    B Joussemet
    Gene Therapy, 2014, 21 : 522 - 528
  • [2] Intracisternal delivery of AAV9 results in oligodendrocyte and Motor neuron transduction in the whole central nervous system of cats
    Bucher, T.
    Dubreil, L.
    Colle, M-A
    Maquigneau, M.
    Deniaud, J.
    Ledevin, M.
    Moullier, P.
    Joussemet, B.
    GENE THERAPY, 2014, 21 (05) : 522 - 528
  • [3] Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs
    T Federici
    J S Taub
    G R Baum
    S J Gray
    J C Grieger
    K A Matthews
    C R Handy
    M A Passini
    R J Samulski
    N M Boulis
    Gene Therapy, 2012, 19 : 852 - 859
  • [4] Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs
    Federici, T.
    Taub, J. S.
    Baum, G. R.
    Gray, S. J.
    Grieger, J. C.
    Matthews, K. A.
    Handy, C. R.
    Passini, M. A.
    Samulski, R. J.
    Boulis, N. M.
    GENE THERAPY, 2012, 19 (08) : 852 - 859
  • [5] Enteric Nervous System Transduction Following Intravascular Delivery of AAV9
    Lampe, S. E. Gombash
    Cowley, C. J.
    Christofi, F. L.
    Fitzgerald, J. A.
    Foust, K. D.
    MOLECULAR THERAPY, 2014, 22 : S91 - S91
  • [6] Transduction and Expression in Brain after Systemic Delivery of Single Stranded AAV9 in Adult Mice
    Keeler, Allison M.
    Sena-Esteves, Miguel
    Conlon, Thomas
    Erger, Kirsten
    Fu Dongtao
    Flotte, Terence R.
    MOLECULAR THERAPY, 2012, 20 : S228 - S228
  • [7] Strong Cortical and Spinal Cord Transduction After AAV7 and AAV9 Delivery into the Cerebrospinal Fluid of Nonhuman Primates
    Samaranch, Lluis
    Salegio, Ernesto A.
    Sebastian, Waldy San
    Kells, Adrian P.
    Bringas, John R.
    Forsayeth, John
    Bankiewicz, Krystof S.
    HUMAN GENE THERAPY, 2013, 24 (05) : 526 - 532
  • [8] Engineered AAV9 Variants for Efficient Muscle Transduction
    Li, Shaoyong
    Chen, Shuyuan
    Li, Zhongwan
    Zhang, Runyuan
    Lan, Xing
    Jiang, Yuling
    Zheng, Yanyan
    Wan, Changpeng
    Pang, Xiaodong
    Wang, Lijun
    Ye, Guo-Jie
    Wu, Zhenhua
    MOLECULAR THERAPY, 2023, 31 (04) : 410 - 411
  • [9] Effect of Age on Intrathecal AAV9 Transduction in Mice
    Garza, Irvin T.
    Holmes, Sydni
    Knight, Krishanna
    Bailey, Rachel M.
    MOLECULAR THERAPY, 2022, 30 (04) : 442 - 443
  • [10] Intracisternal administration of AAV9 gene therapies to target the central nervous system
    Pukenas, Bryan
    Papisov, Mikhail
    Buss, Nicholas
    Karumuthil-Melethil, Subha
    O'Berry, Anthony
    Cowley, Kirsten
    Nevoret, Marie-Laure
    Falabella, Paulo
    MOLECULAR GENETICS AND METABOLISM, 2021, 132 (02) : S89 - S89
12345