Quantification of mouse oxidized low-density lipoprotein by sandwich ELISA

被引：0

作者：

Kato, Rina ^{[1
]}

Mori, Chihiro ^{[1
]}

Kitasato, Keiko ^{[1
]}

Takahashi, Katsuhiko ^{[1
]}

Arata, Satoru ^{[2
]}

Obama, Takashi ^{[1
]}

Itabe, Hiroyuki ^{[1
]}

机构：

[1] Showa Univ, Sch Pharmaceut Sci, Dept Biol Chem, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan

[2] Showa Univ, Lab DNA Recombinat, Shinagawa Ku, Tokyo 1428555, Japan

来源：

NEW FRONTIERS IN LIFESTYLE-RELATED DISEASES | 2008年

关键词：

atherosclerosis; oxidized LDL; ELISA; apoE-KO mouse; oxidized phosphat; idylcholine;

D O I：

10.1007/978-4-431-76428-1_16

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidized low-density lipoprotein (OxLDL) is one of the major factors involved in development of atherosclerosis. A close correlation exists between OxLDL levels in human circulating plasma and occurrence of cardiovascular diseases. To see insight into the patho-physiological feature of diseases, gene engineered animal models, such as apolipoprotein-E knockout mouse, are very powerful tool. We developed an ELISA procedure to measure OxLDL present in mouse circulating plasma, by modification of the previously established method. This method would be a useful tool to study the behavior and function of OxLDL in early development of atherosclerosis.

引用

页码：139 / +

页数：2

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