Is oxidized low-density lipoprotein present in vivo?

被引：0
|
作者：
Yla-Herttuala, S
机构：
[1] Univ Kuopio, AI Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland
[2] Univ Kuopio, Dept Med, FIN-70211 Kuopio, Finland
来源：
CURRENT OPINION IN LIPIDOLOGY | 1998年 / 9卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Basic research has provided strong evidence that oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstantial evidence that oxidized LDL, as measured by serum autoantibody levels, may be associated with the progression of atherosclerotic vascular disease. This review discusses recent findings regarding the presence of oxidized LDL (ox-LDL) in vivo and the significance of ox-LDL autoantibody measurements as a tool to predict cardiovascular diseases in various patient populations. Curr Opin Lipidol 9:337-344. (C) 1998 Lippincott-Raven Publishers.
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页码：337 / 344
页数：8
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