Review of the roles of conjugated linoleic acid in health and disease

被引：179

作者：

Yang, Bo ^{[1
,2
]}

Chen, Haiqin ^{[1
,2
]}

Stanton, Catherine ^{[3
,4
]}

Ross, R. Paul ^{[4
,5
]}

Zhang, Hao ^{[1
,2
]}

Chen, Yong Q. ^{[1
,2
,6
]}

Chen, Wei ^{[1
,2
]}

机构：

[1] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

[2] Synerget Innovat Ctr Food Safety & Nutr, Wuxi 214122, Jiangsu, Peoples R China

[3] Teagasc Moorepk Food Res Ctr, Fermoy, Cork, Ireland

[4] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland

[5] Natl Univ Ireland Univ Coll Cork, Coll Sci Engn & Food Sci, Cork, Ireland

[6] Wake Forest Sch Med, Dept Canc Biol, Winston Salem, NC 27157 USA

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 15卷

基金：

中国国家自然科学基金; 爱尔兰科学基金会;

关键词：

Conjugated linoleic acid; Anti-cancer; Anti-obesity; Health-promoting benefits; KAPPA-B ACTIVATION; TRANS-FATTY-ACIDS; REDUCES BODY-FAT; MIDDLE-AGED MEN; INSULIN-RESISTANCE; PPAR-GAMMA; ADIPOSE-TISSUE; LIPID-METABOLISM; CANCER CELLS; ANTIPROLIFERATIVE ACTIVITY;

D O I：

10.1016/j.jff.2015.03.050

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Dietary fatty acids (FA) are increasingly recognized as major biologic regulators and have properties that relate to health outcomes and disease. Conjugated linoleic acid (CLA) is a generic term denoting a group of isomers of linoleic acid (C18:2, n-6) with a conjugated double bond. CLA has attracted increased research interest because of its health-promoting benefits and biological functions. In a variety of studies, CLA has been shown to impact immune function and has protective effects against cancer, obesity, diabetes, and atherosclerosis in animal studies and in different human cell lines. Studies investigating the mechanisms involved in the biological functions of CLA are emerging with results from both in vivo and in vitro studies. Most of the biological effects have been attributed to the c9,t11-CLA and t10,c12-CLA isomers. The purpose of this review is to discuss the effects of CLA on health and disease and the possible mechanisms for CLA activities. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：314 / 325

页数：12

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