Condom effectiveness in reducing heterosexual HIV transmission: a systematic review and meta-analysis of studies on HIV serodiscordant couples

被引:56
|
作者
Giannou, Foteini K. [1 ,2 ]
Tsiara, Chrissa G. [2 ]
Nikolopoulos, Georgios K. [1 ,2 ]
Talias, Michael [3 ]
Benetou, Vasiliki [1 ]
Kantzanou, Maria [1 ]
Bonovas, Stefanos [4 ]
Hatzakis, Angelos [1 ]
机构
[1] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
[2] Hellen Ctr Dis Control & Prevent, HIV & STIs Off, Athens, Greece
[3] Open Univ Cyprus, Postgrad Program Healthcare Management, Nicosia, Cyprus
[4] Humanitas Clin & Res Ctr, Milan, Italy
关键词
HIV; prevention; condom effectiveness; heterosexual transmission; serodiscordant couples; systematic review; meta-analysis; HUMAN-IMMUNODEFICIENCY-VIRUS; INJECTING DRUG-USERS; SEXUAL TRANSMISSION; FEMALE PARTNERS; LATEX CONDOMS; RISK-FACTORS; ALCOHOL-USE; COITAL-ACT; INFECTION; MEN;
D O I
10.1586/14737167.2016.1102635
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objective: This systematic review and meta-analysis aimed to reassess the effectiveness of condoms in reducing heterosexual transmission of HIV. Methods: Medline, Scopus, and the ISI Web of Science databases were searched up to June 2014. Eligible studies were synthesized using random-effects models. Results: Twenty-five studies with 10,676 HIV serodiscordant heterosexual couples were analyzed. The risk of HIV transmission was considerably lower among couples that were always using condoms compared to never-users (RR:0.29, 95% CI: 0.20-0.43) or inconsistent users (RR: 0.23, 0.13-0.40). The protective effect was slightly higher when the male rather than the female partner was infected (RR:0.31, 0.20-0.48; vs. RR:0.44, 0.24-0.80), and very high in Asian settings (RR:0.06, 0.01-0.46). Conclusions: Though imperfect, condoms reduce HIV transmission by more than 70% when used consistently by HIV serodiscordant heterosexual couples. Social, cultural and biological differences need to be studied further to inform projection modelers and policy makers.
引用
收藏
页码:489 / 499
页数:11
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