SN1-Type Alkylation of N-Heteroaromatics with Alcohols

被引：44
|
作者：
Xiao, Mingyan [1 ]
Ren, Didi [1 ]
Xu, Lubin [1 ]
Li, Shuai-Shuai [1 ]
Yu, Liping [1 ]
Xiao, Jian [1 ]
机构：
[1] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 21期
关键词：
C-H BONDS; IRIDIUM-CATALYZED ALKYLATION; ALPHA-ALKYLATION; FACILE SYNTHESIS; ENANTIOSELECTIVE CONSTRUCTION; ALLYLIC SUBSTITUTION; CONJUGATE ADDITION; SULFONYL ALDIMINES; 2-METHYL AZAARENES; INDOLYL ALCOHOLS;
D O I：
10.1021/acs.orglett.7b02294
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The organocatalytic-alkylation of 2-methyl-N-heteroaroinatics with alcohols has been achieved via S(N)1-type C(sp(3)) H functionalization, providing a green and efficient synthesis of indole and ferrocene-functionalized N-heteroaromatics in high yields.
引用
收藏
页码：5724 / 5727
页数：4
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