Tricyclic HIV integrase inhibitors: Potent and orally bioavailable C5-aza analogs

被引：19

作者：

Jin, Haolun ^{[1
]}

Wright, Matthew ^{[1
]}

Pastor, Richard ^{[1
]}

Mish, Michael ^{[1
]}

Metobo, Sammy ^{[1
]}

Jabri, Salman ^{[1
]}

Lansdown, Rachael ^{[1
]}

Cai, Ruby ^{[1
]}

Pyun, Peter ^{[1
]}

Tsiang, Manuel ^{[1
]}

Chen, Xiaowu ^{[1
]}

Kim, Choung U. ^{[1
]}

机构：

[1] Gilead Sci Inc, Dept Med Chem, Foster City, CA 94404 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 04期

关键词：

D O I：

10.1016/j.bmcl.2008.01.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of C5-aza tricyclic HIV integrase inhibitors was prepared. A highly potent and orally bioavailable compound ( compound 9) was identified and selected for development. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1388 / 1391

页数：4

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