Traversing barriers - How thyroid hormones pass placental, blood-brain and blood-cerebrospinal fluid barriers

被引：48
|
作者：
Landers, Kelly [1 ]
Richard, Kerry [1 ,2 ,3 ]
机构：
[1] Queensland Hlth, Conjoint Endocrine Lab, Chem Pathol, Pathol Queensland, Herston, Qld 4029, Australia
[2] Univ Queensland, Sch Med, Herston, Qld 4029, Australia
[3] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4000, Australia
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2017年 / 458卷 / 0C期
关键词：
Thyroid hormone; Placenta; Brain; Blood-brain barrier; Blood-cerebrospinal fluid barrier; INTRAUTERINE GROWTH RESTRICTION; AMINO-ACID TRANSPORTER; FETAL CEREBRAL-CORTEX; BINDING-PROTEIN TRANSTHYRETIN; CHOROID-PLEXUS; IODOTHYRONINE DEIODINASES; MONOCARBOXYLATE TRANSPORTER-8; THYROXINE TRANSPORT; RING DEIODINATION; RAT-BRAIN;
D O I：
10.1016/j.mce.2017.01.041
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Thyroid hormone is essential for normal human fetal growth and brain development. As the fetal thyroid does not secrete thyroid hormones until about 18 weeks gestation, early fetal brain development depends on passage of maternal hormone across the placenta into the fetal circulation. To reach the fetal brain, maternally derived and endogenously produced thyroid hormone has to cross the blood-brain and blood-cerebrospinal fluid barriers. In this review we will discuss the complex biological barriers (involving membrane transporters, enzymes and distributor proteins) that must be overcome to ensure that the developing human brain has adequate exposure to thyroid hormone. Crown Copyright (C) 2017 Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：22 / 28
页数：7
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