Yellow fever vector live-virus vaccines: West Nile virus vaccine development

被引：45
|
作者：
Arroyo, J [1 ]
Miller, CA [1 ]
Catalan, J [1 ]
Monath, TP [1 ]
机构：
[1] Acambis Inc, Cambridge, MA 02319 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 08期
关键词：
D O I：
10.1016/S1471-4914(01)02048-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
By combining molecular-biological techniques with our increased understanding of the effect of gene sequence modification on viral function, yellow fever 17D, a positive-strand RNA virus vaccine, has been manipulated to induce a protective immune response against viruses of the same family (e.g. Japanese encephalitis and dengue viruses). Triggered by the emergence of West Nile virus infections in the New World afflicting humans, horses and birds, the success of this recombinant technology has prompted the rapid development of a live-virus attenuated candidate vaccine against West Nile virus.
引用
收藏
页码：350 / 354
页数：5
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