Gene expression in nuclear microenvironments for biological control and cancer

The central theme of my research has consistently been to investigate mechanisms that control proliferation and differentiation with emphasis on regulation that is compromised in cancer. Starting as a graduate student, I have been committed to exploring cell cycle and growth control and tissue-specific transcription. And, I have been fortunate, throughout my career, to have colleagues who nurtured an architectural perspective of gene expression providing a novel dimension to the problem from both fundamental biological and clinical perspectives.