Prostaglandin E, transport into rat intestinal cryptic cell line IEC-6

被引：0
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作者：
Hirata, Kohji
Mabashi, Kumiko
Horie, Toshiharu
机构：
来源：
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY | 2005年 / 117卷
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中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Administration of antitumor drugs such as 5-fluorouracil and methotrexate to rats causes intestinal injury. The intestinal injury was reported to be prevented by coadministration of prostaglandin E-1 analogues to rats. IEC-6 cell is a useful in vitro model to study the cytoprotective effect in enterocytes, For its purpose, it is important to know whether or not prostaglandins are taken up into IEC-6 cells. The transport of prostaglandin E-1 into IEC-6 cells was investigated, using [H-3]-prostaglandin E-1. Prostaglandin E-1 was found to be transported into IEC-6 cells by the passive diffusion mechanism.
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页码：115 / 124
页数：10
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