Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase

被引：4
|
作者：
Simonian, Alina [1 ]
Khomutov, Alex [1 ]
Hyvonen, Tapani [2 ]
Grigorenko, Nikolay [1 ]
Keinanen, Tuomo [2 ]
Vepsalainen, Jouko [3 ]
Alhonen, Leena [2 ]
Janne, Juhani [2 ]
机构：
[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia
[2] Univ Kuopio, AI Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland
[3] Univ Kuopio, Dept Chem, FIN-70211 Kuopio, Finland
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 10-12期
基金：
芬兰科学院; 俄罗斯基础研究基金会;
关键词：
polyamines; coenzyme A; SSAT; coenzyme-substrate inhibitors;
D O I：
10.1080/15257770701528214
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New mimics of the transition state of spermine/spermidine-N-1 -acetyltransferase reaction were prepared starting from aminooxy analogues of spermidine or spermine and SH-CoA. The activity depended on the structure of polyamine fragment of the conjugate and best of the synthesized compounds were active at micromolar concentrations.
引用
收藏
页码：1245 / 1248
页数：4
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