Comprehensive identification of high-frequency and combination MHC-DMA and -DMB alleles in a cohort of Chinese rhesus macaques and cynomolgus macaques of Vietnamese origin

被引：2

作者：

Liu, Beilei ^{[1
]}

Jin, Yabin ^{[1
]}

Lu, Yueer ^{[1
]}

Wu, Yiran ^{[1
]}

Xue, Yanxia ^{[1
]}

Zhang, Yonghui ^{[1
]}

Liu, Yang ^{[1
]}

Zhuo, Min ^{[1
]}

Ling, Fei ^{[1
]}

机构：

[1] S China Univ Technol, Sch Biosci & Bioengn, Guangzhou 510006, Guangdong, Peoples R China

来源：

HUMAN IMMUNOLOGY | 2015年 / 76卷 / 2-3期

基金：

中国国家自然科学基金;

关键词：

High-frequency; Major histocompatibility complex class II; Macaca mulatta; Macaca fascicularis; CLASS-II ALLELES; HLA-DM; ASSOCIATION; POPULATION; EXPRESSION; INFECTION; PEPTIDES; GENES; DRA;

D O I：

10.1016/j.humimm.2015.01.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rhesus and cynomolgus macaques are currently used as ideal animal models of immune response. Major histocompatibility complex (MHC) molecules play important roles in the susceptibility and/or resistance to many diseases. In this study, MHC-DMA and -DMB were first characterized by sequencing and cloning in 28 unrelated cynomolgus macaques from Vietnam and 34 unrelated Chinese rhesus macaques. A total of 23 novel alleles, including six high frequency alleles, were identified in this study. Our results showed that the alleles with the highest phenotypic frequencies were Mafa-DMA*02:04:03 (57.1%), Mafa-DMB*03:01:02 (76.9%), Mamu-DMA*02:01:04 (88.2%), and Mamu-DMB*03:02:02 (85%), respectively, indicating that distribution and frequencies of alleles had a few differences between Chinese rhesus macaques and cynomolgus macaques from Vietnam. Interestingly, compared to the cynomolgus macaques, we found that the combination of Mamu-DMA*02:01:04-DMB*03:02:02 was detected in 27 (79.4%) of 34 monkeys, suggesting that the combination of the MHC-DMA and -DMB alleles was probably a characteristic feature of the Chinese rhesus macaques. Our results will greatly increase the value of the two species as models for biomedical research. (C) 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

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页码：109 / 112

页数：4

共 21 条

[21] Identification of Mamu-DPA1, Mamu-DQA1, and Mamu-DRA alleles in a cohort of Chinese rhesus macaques
Deng, Qing
Zhang, Huiling
Xiang, Ruirui
Zhang, Zhenwu
Ling, Fei
Zhuo, Min
Du, Hongli
Wang, Xiaoning
IMMUNOGENETICS, 2013, 65 (12) : 901 - 904

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