Is There a Role for Cellular Therapy in Chronic Lymphocytic Leukemia?

被引：4
|
作者：
Dreger, Peter [1 ]
机构：
[1] Heidelberg Univ, Dept Med 5, Neuenheimer Feld 410, D-69120 Heidelberg, Germany
来源：
CANCER JOURNAL | 2021年 / 27卷 / 04期
关键词：
CAR T-cell therapy; chronic lymphocytic leukemia; CLL; transplantation; BONE-MARROW-TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; MODIFIED T-CELLS; RETROSPECTIVE ANALYSIS; RICHTERS-SYNDROME; FOLLOW-UP; OUTCOMES; CLL; GUIDELINES; COVID-19;
D O I：
10.1097/PPO.0000000000000532
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite multiple advances in the treatment landscape of chronic lymphocytic leukemia (CLL) during recent years, cellular therapies, such as allogeneic hematopoietic cell transplantation and chimeric antigen-engineered T cells, represent valuable therapeutic options for patients with multiply relapsed or poor-risk disease. This brief overview will summarize current results of cellular therapies in CLL including Richter transformation, suggest an indication algorithm and strategies for performing cellular therapies in these conditions, and discuss the impact of COVID-19 (coronavirus disease 2019) on allogeneic hematopoietic cell transplantation and chimeric antigen-engineered T cells in CLL.
引用
收藏
页码：297 / 305
页数：9
相关论文
共 50 条
  • [41] INTENSIVE THERAPY OF CHRONIC LYMPHOCYTIC-LEUKEMIA
    GALE, RP
    MONTSERRAT, E
    [J]. BAILLIERES CLINICAL HAEMATOLOGY, 1993, 6 (04): : 879 - 885
  • [42] Monoclonal antibody therapy of chronic lymphocytic leukemia
    Cheson, BD
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2006, 55 (02) : 188 - 196
  • [43] Monoclonal antibody therapy of chronic lymphocytic leukemia
    Mavromatis, B
    Cheson, BD
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (09) : 1874 - 1881
  • [44] CHLORAMBUCIL THERAPY FOR LYMPHOMAS AND CHRONIC LYMPHOCYTIC LEUKEMIA
    EZDINLI, EZ
    STUTZMAN, L
    [J]. JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1965, 191 (06): : 444 - &
  • [45] Monoclonal antibody therapy of chronic lymphocytic leukemia
    Bruce D. Cheson
    [J]. Cancer Immunology, Immunotherapy, 2006, 55 : 188 - 196
  • [46] Targeted Therapy in Chronic Lymphocytic Leukemia (CLL)
    Erin M. Pettijohn
    Shuo Ma
    [J]. Current Hematologic Malignancy Reports, 2017, 12 : 20 - 28
  • [47] The future of antibody therapy in chronic lymphocytic leukemia
    Crombie, Jennifer L.
    Brown, Jennifer R.
    [J]. EXPERT OPINION ON EMERGING DRUGS, 2021, 26 (03) : 323 - 336
  • [48] VINCRISTINE THERAPY OF LYMPHOMAS AND CHRONIC LYMPHOCYTIC LEUKEMIA
    DESAI, DV
    EZDINLI, EZ
    STUTZMAN, L
    [J]. CANCER, 1970, 26 (02) : 352 - &
  • [49] Targeted Therapy in Chronic Lymphocytic Leukemia (CLL)
    Pettijohn, Erin M.
    Ma, Shuo
    [J]. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 2017, 12 (01) : 20 - 28
  • [50] STAGING AND THERAPY OF CHRONIC LYMPHOCYTIC-LEUKEMIA
    FOON, KA
    GALE, RP
    [J]. SEMINARS IN HEMATOLOGY, 1987, 24 (04) : 264 - 274
12345