Design and optimization of coagulation factor XIa inhibitors: Discovery of trans-N-((S)-1-(4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl)-2-phenylethyl)-4-(aminomethyl)cyclohexane-carboxamide, a potent factor XIa inhibitor with in vivo antithrombotic activity

被引：0
|
作者：
Hangeland, Jon J. [1 ]
Friends, Todd J. [1 ]
Rossi, Karen A. [1 ]
Smallheer, Joanne M. [1 ]
Wang, Cailan [1 ]
Sun, Zhong [1 ]
Fang, Tianan [1 ]
Corte, James R. [1 ]
Wong, Pancras C. [1 ]
Rendina, Alan R. [1 ]
Luettgen, Joseph M. [1 ]
Barbera, Frank A. [1 ]
Bozarth, Jeffrey M. [1 ]
Watson, Carol A. [1 ]
Zhang, Ge [1 ]
Wei, Anzhi [1 ]
Morin, Paul F. [1 ]
Bisacchi, Gregory S. [1 ]
Seiffert, Dietmar A. [1 ]
Wexler, Ruth R. [1 ]
Quan, Mimi L. [1 ]
机构：
[1] Bristol Myers Squibb Co, Res & Dev, Princeton, NJ 08543 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 247卷
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D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
216-MEDI
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页数：1
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