Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

被引：8
|
作者：
Chen, Alice [1 ]
Smith, Kenneth P. [2 ]
Whitfield, Betsy A. [1 ]
Zucchi, Paola C. [1 ]
Lasco, Todd M. [3 ]
Bias, Tiffany E. [4 ,5 ]
Kirby, James E. [2 ,6 ]
Hirsch, Elizabeth B. [1 ,2 ]
机构：
[1] Northeastern Univ, Boston, MA 02115 USA
[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[3] CHI Baylor St Lukes Med Ctr, Houston, TX USA
[4] Med Coll Penn & Hahnemann Univ, Philadelphia, PA 19102 USA
[5] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA
[6] Harvard Med Sch, Boston, MA USA
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2017年 / 88卷 / 04期
关键词：
Extended-spectrum beta-lactamase; Multidrug resistance; KPC; Tetracycline; Resistant; RESISTANT; INFECTIONS; SUSCEPTIBILITY; USA;
D O I：
10.1016/j.diagmicrobio.2017.05.004
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)producing Enterobacteriaceae isolates and found approximately half had susceptible (26%) or intermediate (26%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71% FDA vs. 20% EUCAST) followed by minocycline (14%) and then doxycycline (6%). (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：365 / 367
页数：3
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