Quantitative liquid chromatography/time-of-flight mass spectrometry

被引：52
|
作者：
Williamson, Leah N. [1 ]
Bartlett, Michael G. [1 ]
机构：
[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA
来源：
BIOMEDICAL CHROMATOGRAPHY | 2007年 / 21卷 / 06期
关键词：
liquid chromatography; time-of-flight mass spectrometry; quantitation;
D O I：
10.1002/bmc.844
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the last decade, time-of-flight (TOF) instruments have increasingly been used as quantitation tools. In addition, because of their high resolving power, they can be used for verification of empirical formulas. Historically, TOF instruments have had limited quantitation capabilities because of their narrow dynamic ran e. However, recent advances have improved these limitations. This review covers the rationale for using TOF for LC detection, and describes the many methods currently in the literature for the quantitation of pharmaceuticals, environmental pollutants, explosives and many phytochemicals. Copyright (c) 2007 John Wiley & Sons, Ltd.
引用
收藏
页码：567 / 576
页数：10
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