The Contribution of Lipotoxicity to Diabetic Kidney Disease

被引：31
|
作者：
Schelling, Jeffrey R. [1 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA
来源：
CELLS | 2022年 / 11卷 / 20期
关键词：
cholesterol esters; diabetic kidney disease; fatty acids; lipid droplets; podocyte; proximal tubule; RENAL LIPID-METABOLISM; TUBULAR EPITHELIAL-CELLS; ENDOPLASMIC-RETICULUM STRESS; BOUND FATTY-ACIDS; PROXIMAL TUBULE; CANNABINOID RECEPTOR; INJURY MOLECULE-1; FENOFIBRATE THERAPY; PODOCYTE INJURY; LDL CHOLESTEROL;
D O I：
10.3390/cells11203236
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) pathogenesis. This review highlights lipotoxicity pathways in the podocyte and proximal tubule cell, which are arguably the two most critical sites in the nephron for DKD. The discussion focuses on membrane transporters and lipid droplets, which represent potential therapeutic targets, as well as current and developing pharmacologic approaches to reduce renal lipotoxicity.
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页数：19
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