A novel synthesis of 3-((benzo[d]thiazol-2-ylamino)(phenyl)methyl)-4-hydroxy-1-methylquinolin-2(1H)-one via consecutive C-C and C-N bond formation in water

被引：4
|
作者：
Yadav, Maruti B. [1 ]
Vagh, Sandip S. [2 ]
Jeong, Yeon Tae [1 ]
机构：
[1] Pukyong Natl Univ, Dept Image Sci & Engn, Busan 608737, South Korea
[2] CSIR Natl Chem Lab, Organ Chem Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2020年 / 46卷 / 08期
关键词：
Green solvent; Quinolines; Thiazole; 4-Hydroxy-1-methylquinolin-2(1H)-one; Multicomponent reactions (MCRs); GREEN SYNTHESIS; DOMINO REACTION; SOLVENT; DERIVATIVES; CATALYST; CONSTRUCTION; ANTICANCER; FORMALDEHYDE; INHIBITORS; DISCOVERY;
D O I：
10.1007/s11164-020-04173-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple, efficient, and eco-friendly protocol has been developed for the synthesis of novel 3-((benzo[d]thiazol-2-ylamino)(4-methoxyphenyl)methyl)-4-hydroxy-1-methylquinolin-2(1H)-one derivatives using a one-pot C-C and C-N bond forming strategy from the reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, 2-aminobenzothiazole and aromatic aldehydes in aqueous solvent without using any metal catalyst. Several advantages of this protocol include its operational simplicity, short reaction time, mild reaction condition, efficient utilization of all the reactants, wide functional group tolerance, using water as an environmentally friendly solvent and non-chromatographic purification procedure. [GRAPHICS] .
引用
收藏
页码：3801 / 3815
页数：15
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