Emergence of Vaccine-Derived Polioviruses during Ebola Virus Disease Outbreak, Guinea, 2014-2015

被引：9
|
作者：
Fernandez-Garcia, Maria Dolores [1 ]
Majumdar, Manasi [2 ]
Kebe, Ousmane [1 ]
Fall, Aichatou D. [1 ]
Kone, Moussa [3 ]
Kande, Mouctar [3 ]
Dabo, Moustapha [4 ]
Sylla, Mohamed Salif [4 ]
Sompare, Djenou [4 ]
Howard, Wayne [5 ]
Faye, Ousmane [1 ]
Martin, Javier [2 ]
Ndiaye, Kader [1 ]
机构：
[1] Inst Pasteur, Dakar, Senegal
[2] Natl Inst Biol Stand & Controls, Potters Bar, Herts, England
[3] WHO, Conakry, Guinea
[4] Guinean Minist Hlth, Conakry, Guinea
[5] Natl Inst Communicable Dis, Johannesburg, South Africa
来源：
EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 01期
关键词：
WORLDWIDE; UPDATE; IDENTIFICATION; POLIOMYELITIS; STRAIN; CHILD;
D O I：
10.3201/eid2401.171174
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
During the 2014-2015 outbreak of Ebola virus disease in Guinea, 13 type 2 circulating vaccine-derived polioviruses (cVDPVs) were isolated from 6 polio patients and 7 healthy contacts. To clarify the genetic properties of cVDPVs and their emergence, we combined epidemiologic and virologic data for polio cases in Guinea. Deviation of public health resources to the Ebola outbreak disrupted polio vaccination programs and surveillance activities, which fueled the spread of neurovirulent VDPVs in an area of low vaccination coverage and immunity. Genetic properties of cVDPVs were consistent with their capacity to cause paralytic disease in humans and capacity for sustained person-toperson transmission. Circulation ceased when coverage of oral polio vaccine increased. A polio outbreak in the context of the Ebola virus disease outbreak highlights the need to consider risks for polio emergence and spread during complex emergencies and urges awareness of the challenges in polio surveillance, vaccination, and diagnosis.
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页码：65 / 74
页数：10
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