Inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro

被引：32
|
作者：
Du, ZY [1 ]
Li, XY [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
来源：
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1999年 / 21卷 / 03期
关键词：
indomethacin; interleukin-1; tumor necrosis factor-alpha; nitric oxide; microglia;
D O I：
10.1016/S0192-0561(98)00084-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Indomethacin, as a nonsteroidal antiinflammatory drug, is reported to be effective in some degree in the prevention and treatment of Alzheimer's disease (AD). Effects of indomethacin on proinflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor alpha and nitric oxide (NO) on rat microglia in vitro were investigated. The biological activities of IL-1 were assayed by thymocyte proliferation assay and the activities of TNG-alpha, by L929 cytotoxicity assay. NO concentration was represented by nitrite and determined by Griess reaction. Indomethacin inhibited IL-1 and NO production by rat microglia stimulated at the concentration of 0.1-10 mu mol/l. However, it did not show any inhibitory effect on TNF-alpha production by resting and LPS-stimulated rat microglia. The results suggest that the mechanism by which indomethacin might be beneficial in treatment of AD might be due to the inhibition IL-1 and NO production from microglia. (C) 1999 International Society for Immunopharmacology. Published by Elsevier Science Ltd.
引用
收藏
页码：219 / 225
页数：7
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