Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro

被引：0

作者：

Du, ZY ^{[1
]}

Li, XY ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 1998年 / 19卷 / 05期

关键词：

ginkgolides; platelet-activating factor; nitroarginine; nitric oxide; microglia; lipopolysaccharides; cultured cells; apafant;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

AIM: To study the effects of ginkgolide A (GA) and B (GB), apafant (Apa), and N omega-nitro-L-arginine (L-NA) on nitric oxide (NO) production in cultured neonatal rat microglia. METHODS: NO concentration was represented by nitrite which was determined by Griess reaction. RESULTS: In resting microglia, no inhibitory effects of GA, GB, and Apa were observed. L-NA inhibited NO production, its IC50 value (95 % confidence limits) being 3.4 (0.8-14.9) mu mol . L-1 GA, GB, and L-NA inhibited NO production in LSS-stimulated microglia, and their IC50 values (95 % confidence limits) were 5.7 (1.8 - 18.1), 1.1 (0.3 - 4.4), and 0.5 (0.1 - 2.8) mu mol . L-1, respectively. Apa did not inhibit NO production. CONCLUSION: GA and GB inhibited NO production in LPS-stimulated microglia.

引用

页码：467 / 470

页数：4

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