Copper-Catalyzed Decarboxylative Alkylation of Terminal Alkynes

被引：34
|
作者：
Ye, Changqing [1 ]
Li, Yajun [1 ]
Bao, Hongli [1 ]
机构：
[1] Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Key Lab Coal Ethylene Glycol & Its Related Techno, 155 Yangqiao Rd West, Fuzhou 350002, Fujian, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 21期
关键词：
Copper-catalysis; Alkylation; Sonogashira coupling; Decarboxylation; CROSS-COUPLING REACTIONS; LIGHT PHOTOREDOX CATALYSIS; ALPHA-AMINO-ACIDS; C-H BONDS; VISIBLE-LIGHT; GRIGNARD-REAGENTS; SONOGASHIRA REACTIONS; C(SP(3))-H BONDS; HALIDES; BROMIDES;
D O I：
10.1002/adsc.201700798
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A copper-catalyzed decarboxylative alkylation of terminal alkynes under mild reaction conditions has been reported. Various alkyl diacyl peroxides were applied as the alkyl source for the formation of C(sp(3))-C(sp) bond. A range of terminal alkynes including aryl alkynes and alkyl alkynes delivered the alkylated internal alkynes with good to high performances. Mechanism studies suggested that this reaction involves a free radical pathway.
引用
收藏
页码：3720 / 3724
页数：5
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